![]() shortness of breath and malaise from not having enough red blood cells ( anemia).Sometimes, your bone marrow becomes overcrowded with the large number of T cells, so fewer red blood cells and platelets can be produced. So-called B-cell symptoms can develop, which include: But symptoms may appear as the illness progresses. Symptoms commonly associated with most other types of leukemia and lymphoma are uncommon in the early stages of T-PLL. swelling and edema in your legs, the skin around your eyes, or the membrane covering your eye (conjunctiva).fluid buildup in your abdominal cavity ( ascites) or around your lungs ( pleural effusion).a rash or other skin lesion caused by white blood cells moving into your skin tissue.When symptoms are present, they might include: This usually happens within 2 years of developing a high white blood cell count. This is called inactive T-PLL.Įventually, though, the disease becomes active and causes symptoms. In this instance, T-PLL is stable or only progresses slowly. Up to 30 percent of people with T-PLL have a high white blood cell count but no other symptoms. The most common symptom of T-PLL is an extremely high white blood cell count (lymphocytosis) of about 100,000 cells/microliter (mL) or more. In the rest of this article, we’ll focus on T-PLL when describing T-cell leukemia. T-cell prolymphocytic leukemia (T-PLL) is a good example of cancer that affects your T cells, and it’s been studied more than other types. Most lymphocytic leukemias involve B cells, but there are a few T-cell leukemias. Lymphoma develops when this process occurs in a lymph node or other lymphatic tissue. The result is a large number of abnormal copies of the cell in your bone marrow and bloodstream. Instead of maturing, the damaged DNA tells these cells to multiply uncontrollably. ![]() Lymphocytic leukemia develops when the DNA in precursor cells change (mutate) or become damaged. Other precursor cells leave your bone marrow and travel to your thymus where they become mature T cells. Some of these stay in your bone marrow and become mature B cells. Primitive stem cells form there and develop into immature precursor cells. The four main types of leukemias that can develop include:īlood cells are made in your bone marrow. ![]()
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